ALMITRINE DIMESILATE
N,N'-diallyl-6-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1,3,5-triazine-2,4-diamine dimethanesulphonate
CAS: 29608-49-9
Molecular Formula: C28H37F2N7O6S2
ALMITRINE DIMESILATE - Names and Identifiers
| Name | N,N'-diallyl-6-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1,3,5-triazine-2,4-diamine dimethanesulphonate |
| Synonyms | Mesylate AlMitrine ALMITRINE DIMESYLATE ALMITRINE DIMESILATE Almitrine Dimesylate ALMITRINE BISMESYLATE Almitrine bismethanesulfonate 2,4-bis(allylamino)-6-[4-[bis(p-fluorophenyl)methyl]-1-piperazinyl]-s-triazine dimethanesulfonate N,N'-diallyl-6-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1,3,5-triazine-2,4-diamine dimethanesulphonate n,n'-diallyl-6-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1,3,5-triazine-2,4-diamine dimethanesulphonate N2,N4-Diallyl-6-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-1,3,5-triazine-2,4-diamine dimethanesulfonate 6-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-N,N'-diprop-2-en-1-yl-1,3,5-triazine-2,4-diamine dimethanesulfonate |
| CAS | 29608-49-9 |
| EINECS | 249-726-1 |
| InChI | InChI=1/C26H29F2N7.2CH4O3S/c1-3-13-29-24-31-25(30-14-4-2)33-26(32-24)35-17-15-34(16-18-35)23(19-5-9-21(27)10-6-19)20-7-11-22(28)12-8-20;2*1-5(2,3)4/h3-12,23H,1-2,13-18H2,(H2,29,30,31,32,33);2*1H3,(H,2,3,4) |
ALMITRINE DIMESILATE - Physico-chemical Properties
| Molecular Formula | C28H37F2N7O6S2 |
| Molar Mass | 669.76 |
| Melting Point | 243° (dec) |
| Boling Point | 606.2°C at 760 mmHg |
| Flash Point | 320.4°C |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 1.21E-14mmHg at 25°C |
| Appearance | Solid |
| Color | White |
| Storage Condition | Sealed in dry,Room Temperature |
| In vitro study | Almitrine inhibits the activity of a high-conductance (152±13 pS), Ca 2+ -dependent K + channel by decreasing its open probability. The IC 50 value of the effect is 0.22 μM. The inhibitory effect of Almitrine on Ca 2+ -dependent K + channels also is observed in GH3 cells. Almitrine at concentrations up to 10 μM does not affect whole-cell voltage-dependent K + , Ca 2+ , or Na + currents in rat or rabbit cells. However, this concentration of Almitrine significantly inhibits the Ca 2+ -dependent component of K + currents in rat chemoreceptor cells. |
| In vivo study | Almitrine acts via the peripheral arterial chemoreceptors raising carotid sinus nerve output and minute ventilation. Almitrine also has a pulmonary vascular action causing a dose-dependent constriction and dilatation. At low doses Almitrine enhances hypoxic pulmonary vasoconstriction and may improve the overall ventilation/perfusion ratio. |
ALMITRINE DIMESILATE - Risk and Safety
| Toxicity | LD50 in mice: 210 mg/kg i.v., 390 mg/kg i.p., >2 g/kg orally (Regnier) |
ALMITRINE DIMESILATE - Standard
Authoritative Data Verified Data
This product is 2, 4-bis (allylamino)-6-[4-bis-(p-fluorophenyl)] methyl]-L-piperazinyl-S-tricresyl-bis-methanesulfonate. The content of C26H29F2N7 • 2CH3S03H shall be 98.0% ~ 102.0% calculated as dry product.
Last Update：2024-01-02 23:10:35
ALMITRINE DIMESILATE - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline powder; Odorless.
- This product is soluble in methanol or three gas methane, soluble in ethanol, slightly soluble in acetone, insoluble in water.
Last Update：2022-01-01 11:29:41
ALMITRINE DIMESILATE - Differential diagnosis
Authoritative Data Verified Data
- take about 0.2g of this product, put it in a test tube, and heat it with small fire to melt it. The gas generated should make the wet lead acetate test paper black.
- take this product, add ethanol to make a solution containing 8ug per 1 ml, according to ultraviolet-visible spectrophotometry (General 0401), there is a maximum absorption at the wavelength of 223nm.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 900).
Last Update：2022-01-01 11:29:42
ALMITRINE DIMESILATE - Exam
Authoritative Data Verified Data
acidity
take 0.50g of this product, add 50ml of water, shake for 10 minutes, filter, take the filtrate, according to the law (General 0631),pH value should be 2.0~3.5.
cyanogen content
take this product about 35mg, precision weighing, according to the fluorine inspection method (General 0805) determination, fluorine content should be 5.1% ~ 6.3%.
Related substances
take about 30mg of this product, put it in a 100ml measuring flask, add the mobile phase to dissolve and dilute to the scale, shake well, and use it as a test solution, set in a 100ml measuring flask and dilute to the scale with the mobile phase as a control solution. According to the chromatographic conditions under the content determination item, 20ul of the test solution and the control solution are accurately measured, and the human liquid chromatograph is injected respectively, and the chromatogram is recorded to 2 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.5 times (0.5%) of the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than 1.5 times (1.5%) of the main peak area of the control solution.
residual solvent
take this product, precision weighing, add dimethyl sulfoxide to dissolve and make a solution containing 20mg per 1ml, according to the residual solvent determination method (General 0861), the residual amount of toluene should be in accordance with the regulations.
chloride
take 0.50g of this product and add 25ml of ethanol to dissolve it. In addition to diluting it with ethanol, check it according to law (General rule 0801), and compare it with the control solution made of standard sodium chloride solution, no more concentrated (0.01%).
sulfate
take 0.50g of this product, add 50ml of water, slowly boil for 2 minutes, let it cool, add additional water to the original volume, shake, filter, take 40ml of filtrate, inspection according to law (General rule 0802), compared with the standard potassium sulfate solution 0.05% ML made of control solution, should not be more concentrated ().
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.15%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 20 parts per million of heavy metal when examined by law (General rule 0821, Law II).
Last Update：2022-01-01 11:29:43
ALMITRINE DIMESILATE - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica as filler; Methanol-water (85:15 )(5ul of diethylamine added per 1000ml) as mobile phase; the detection wavelength was 222nm. The number of theoretical plates is not less than 900 calculated from the peak of amitrizine.
- determination of this product, precision weighing, plus mobile phase dissolution and quantitative dilution into each 1ml containing about 0.12mg of solution, precision volume of 20ul injection liquid chromatography, record chromatogram; take the other two dimethyl sulfonic acid amitriptan reference substance, the same method for determination. According to the external standard method to calculate the peak area, that is.
Last Update：2022-01-01 11:29:44
ALMITRINE DIMESILATE - Category
Authoritative Data Verified Data
Central stimulant.
Last Update：2022-01-01 11:29:44
ALMITRINE DIMESILATE - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:29:44
ALMITRINE DIMESILATE - Reference Information
| Biological activity | Almitrine mesylate is an agonist of peripheral chemoreceptors that selectively inhibits Ca2 +-dependent K channels. |
| target | K channel |
| category | toxic substances |
| toxicity classification | highly toxic |
| acute toxicity | oral administration-mouse LD50: 2000 mg/kg; Abdominal cavity-mouse LD50: 370 mg/kg |
| flammability hazard characteristics | combustible; combustion produces toxic nitrogen oxides, sulfur oxides and fluoride smoke |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; separate from food raw materials |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |
Last Update：2024-04-09 19:05:11
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Product Name: Almitrine bismesylate; Almitrine bismethanesulfonate; Almitrine dimesylate Visit Supplier Webpage Request for quotationCAS: 29608-49-9
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Product Name: Almitrine dimesylate Visit Supplier Webpage Request for quotationCAS: 29608-49-9
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Product List: View Catalog
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Product Name: Almitrine dimesylate Visit Supplier Webpage Request for quotationCAS: 29608-49-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
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Product Name: Almitrine dimesylate Visit Supplier Webpage Request for quotationCAS: 29608-49-9
Tel: +86-18821248368
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Mobile: +86-18821248368
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CAS: 29608-49-9
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View History
ALMITRINE DIMESILATE
反式-2-(3,5-二甲氧基苯基)环丙烷-1-羧酸
(E)-2-氯-3-(羟亚甲基)环己基-1-烯-1-甲醛
2-[1-[(叔丁氧羰基氨基)甲基]环己基]乙酸
4-氧代-3-苄氧基-4H-吡喃-2,5-二甲酸二甲酯
DODECYLETHYLDIMETHYLAMMONIUM BROMIDE
4-甲氧基苄氯(含稳定剂戊烯)
LABOTEST-BB LT00786416
2-氰基吡啶-4-羧酸
FMOC-9-氨基-4,7-二噁壬酸
反式-2-(3,5-二甲氧基苯基)环丙烷-1-羧酸
(E)-2-氯-3-(羟亚甲基)环己基-1-烯-1-甲醛
2-[1-[(叔丁氧羰基氨基)甲基]环己基]乙酸
4-氧代-3-苄氧基-4H-吡喃-2,5-二甲酸二甲酯
DODECYLETHYLDIMETHYLAMMONIUM BROMIDE
4-甲氧基苄氯(含稳定剂戊烯)
LABOTEST-BB LT00786416
2-氰基吡啶-4-羧酸
FMOC-9-氨基-4,7-二噁壬酸